When the husband’s sperms have poor motility or the count is very low, IVF will not work. In these situations, ICSI is the only option. ICSI is a procedure in which a single sperm is injected into an egg i.e. fertilization is done by humans. The resulting embryo is then transferred back into the uterus. This is carried out in laboratory using a specially adapted microscope. ICSI is advised for couples where the sperm quantity or quality is very poor, or when IVF has resulted in failed fertilization. It is also used when the sperm has been collected by surgical sperm retrieval.